Are Labrador Retrievers prone to obesity?

Labrador Retrievers: Are They Prone to Obesity?

A study in Cell Metabolism found that 25% of Labrador retrievers have a gene linked to obesity1. This might be why Labradors are more likely to get fat than other dogs2. Obesity in Labradors is common, with rates in developed countries between 34% and 59%2.

Key Takeaways

  • About a quarter of Labrador retrievers have a genetic variant in the POMC gene that predisposes them to obesity3.
  • Labrador retrievers with the POMC mutation tend to be more food-motivated, spending less time resting or exploring and more time attempting to get at the food3.
  • Dogs with the POMC mutation burn around 25% fewer calories than dogs without the mutation31.
  • The POMC mutation was found in about 23% of Labrador retrievers sampled from the UK and USA2.
  • Labrador retrievers with the POMC mutation may be more likely to be chosen as assistance dogs due to their increased food motivation2.

Introduction to Labrador Retrievers and Obesity

Prevalence of Obesity in Dogs

Obesity is a big problem for dogs around the world. In places like the UK, about 40% of dogs are overweight. This can lead to serious health issues like diabetes and heart disease4.

Just like humans, dogs are getting fatter because they don’t exercise enough and eat too many treats4. Some dog breeds are more likely to get fat, and Labrador retrievers are one of them4.

Research shows that obesity in dogs is partly due to their genes. It’s estimated that 51% of a dog’s weight is influenced by genetics4. Breeds like Labradors, Golden retrievers, and Pugs are more likely to get fat4. Even the smallest Labradors can grow up to be overweight4.

The rate of obesity in dogs varies. In the Netherlands, 40% of dogs are overweight, and 20% are obese4. In Beijing, over 40% of dogs suffer from obesity4.

“Canine obesity has an average heritability of body weight estimated at 51%, with a range of 35%-70% across 19 breeds.”4

Genetic Factors in Obesity-Prone Dog Breeds

While diet and exercise are important, some dog breeds are more likely to get fat. Labrador retrievers are a prime example, showing a genetic link to obesity5.

The 14 base pair deletion in the POMC gene is common in Labradors, affecting their hormones5. Obesity in dogs is widespread, with Labradors leading the pack5.

This POMC mutation is more common in Labradors used as service dogs than as pets5. It makes them gain weight and crave food more5. In fact, it’s linked to higher body weight and a bigger appetite in Labradors and flat-coat retrievers5.

Labradors and flat-coat retrievers both have this mutation, which affects their weight and food drive5. The Dog Obesity Risk Assessment shows this mutation makes them more food-motivated5.

Flat-coat retrievers have a 60% chance of having this POMC deletion5. This mutation is linked to their weight and food cravings5.

Labradors and flat-coat retrievers share a common ancestor with this mutation5. This genetic link explains why they are more prone to obesity6.

Breed POMC Deletion Frequency Association with Obesity
Labrador Retrievers 12% allele frequency5 Highest obesity prevalence among dog breeds studied5
Flat-Coat Retrievers 60% allelic frequency5 POMC deletion associated with higher body weight and food motivation5

“Around one in four Labradors (23%) is thought to carry at least one copy of the genetic variant associated with weight, obesity, and appetite.”6

Research on Labrador retrievers and flat-coat retrievers sheds light on obesity genetics56. It shows how the POMC gene affects their weight and appetite56.

The POMC Gene and Its Role in Energy Homeostasis

The POMC gene is key in controlling how much we eat and our energy balance. Problems with the POMC gene and other parts of the brain’s energy system can cause severe obesity in both animals and humans7. Changes in the POMC gene have also been linked to weight differences in people7.

The Hypothalamic Leptin Melanocortin Signalling Pathway

The brain’s energy balance system is crucial. Leptin, made by fat cells, tells the brain to make POMC peptides. These peptides, like α-MSH, work with the brain’s MC4R to reduce hunger and boost energy use7.

Statistic Value
Labradors carrying POMC mutation More than 10% of Labradors and flat-coated retrievers carry a POMC mutation that abolishes the production of β-MSH and β-endorphin without affecting α-MSH production7.
Resting metabolic rate in POMC mutation carriers POMC mutation carriers had substantially lower resting metabolic rates, indicating that they burned fewer calories compared to non-carriers7.
Effect of setmelanotide on energy expenditure Setmelanotide, an MC4R agonist approved for certain forms of obesity caused by single-gene mutations, has shown clear effects on energy expenditure in canine models with defective melanocortin systems7.

Research on dog obesity could help find new treatments for human obesity7. Hundreds of genetic links to obesity have been found in both humans and dogs. This shows how complex the relationship between genes and health is7. Scientists are working to understand this better, hoping to improve health for both humans and animals7.

“Genetic associations between obesity in dogs and humans could provide insights for developing new pharmacological treatments for obesity.”

Identification of a POMC Deletion in Obese Labrador Retrievers

Scientists have found a key genetic link to obesity in Labrador retrievers. A 14 base-pair deletion in the POMC gene is the culprit8. This deletion was seen in 10 out of 15 obese Labradors but only in 2 out of 18 lean ones8.

This deletion messes with the production of important peptides. These peptides, β-MSH and β-endorphin, help control hunger and fullness after eating.

Obesity is a big problem in dogs, with up to 40% of Dutch dogs being overweight or obese9. Labrador retrievers, Golden retrievers, Pugs, and Beagles are especially at risk. This shows that genetics play a big role in their weight gain9.

Breed Prevalence of Obesity
Labrador Retrievers High
Golden Retrievers High
Pugs High
Beagles High

Finding the POMC deletion in obese Labradors is a big breakthrough. It helps us understand why this breed is more likely to gain weight8. More research is needed to grasp how genetics, environment, and obesity interact in dogs.

“The discovery of a POMC deletion in obese Labrador retrievers is a significant step forward in understanding the genetic basis of obesity in this breed.”

POMC deletion in Labrador retrievers

As obesity becomes more common in humans and dogs, finding genetic markers like the POMC deletion is crucial. It could lead to new ways to fight obesity through targeted treatments and breeding910.

Are Labrador Retrievers Prone to Obesity?

Labrador retrievers are known for their friendly nature and love for water. Sadly, they are also at a higher risk of obesity11. Almost 60 percent of Labradors are overweight or obese, which is a worrying fact11. Their genetic makeup might be the reason behind this.

A study on 310 Labrador retrievers showed many lacked the POMC gene11. This gene is key for controlling appetite and fat sensing11. The POMC deletion is common in Labradors and their cousin, the flat-coated retriever11. This suggests a genetic link to weight gain and food cravings.

Dogs with the POMC deletion were, on average, 1.9 kilograms heavier12. They also had a higher body condition score, showing more fat12. These dogs were more likely to look for food, showing their strong food motivation12.

Obesity is a big problem in dogs, not just Labradors12. In rich countries, up to two-thirds of dogs are overweight12. But Labradors have the highest obesity rates among all breeds12.

The study on the POMC gene in Labradors and flat-coated retrievers was published in Science Advances12. It sheds light on the genetic causes of obesity in these breeds12. This knowledge can help breeders and veterinarians tackle the obesity problem in these dogs.

The POMC Deletion in Flat-Coat Retrievers

The pro-opiomelanocortin (POMC) deletion was found in flat-coat retrievers but not in 38 other breeds13. In 96 unrelated flat-coat retrievers, 60% had the POMC deletion13. This mutation was linked to higher body weight and more food interest in these dogs13.

This genetic issue is common in flat-coat retrievers. It’s not seen in nearly 40 other dog breeds14. It’s unique to Labrador retrievers and their relatives, the flat-coat retrievers.

Breed POMC Deletion Prevalence
Labrador Retrievers Approximately 25% carry the mutation14
Service Dogs 76% carry the POMC genetic mutation14
Flat-Coat Retrievers 60% allelic frequency of the POMC deletion13

The POMC deletion is common in Labrador and flat-coat retrievers1314. It leads to more weight and a bigger appetite in these dogs13. This makes it hard for breeders and owners to keep their dogs healthy and happy.

Discovering the POMC deletion in flat-coat retrievers is a big find1314. It shows we need to learn more about how genetics affect obesity in dogs1314. Knowing more about this can help breeders and owners keep their dogs healthy and happy.

Prevalence of the POMC Deletion in Labrador and Flat-Coat Retrievers

Recent studies have uncovered a genetic mutation linked to obesity in Labrador and Flat-Coat Retrievers. The POMC deletion mutation, first identified in 2016 by Raffan et al15., affects a significant number of these breeds. It leads to increased hunger and weight gain.

In a study of 310 Labrador Retrievers, the POMC deletion was found in about 23% of the dogs15. Examining 411 dogs from the UK and US, including 38 other breeds, revealed a unique prevalence in Labrador and Flat-Coat Retrievers16. This mutation is found in 1 in 4 Labrador Retrievers and 2 in 3 Flat-Coated Retrievers16.

The POMC deletion mutation disrupts the β-MSH and β-endorphin coding sequences. This leads to increased hunger, food motivation, and higher body weight in affected dogs15. This genetic predisposition to obesity is a significant concern for these breeds. It can impact their health and well-being if not managed properly.

Breed POMC Deletion Prevalence
Labrador Retrievers 23%15
Flat-Coat Retrievers 67%16

The findings highlight the need for more research into obesity in these breeds. We also need targeted interventions to address this growing concern.

“The POMC deletion mutation disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight, adiposity, and greater food motivation in Labrador Retrievers and Flat-coated Retrievers.”15

Implications for Assistance Dog Breeding

The POMC mutation is more common in Labrador retrievers meant to be assistance dogs17. A study showed that 76% of 81 assistance Labradors had the POMC deletion17. It’s thought that these dogs might be more eager to eat, which could be why they’re chosen for training17.

The POMC Deletion and Assistance Dog Selection

The POMC deletion is very common in assistance Labradors17. This gene makes dogs more interested in food, which might be why they’re picked for assistance work17. This is something to think about when breeding and training these dogs17.

POMC deletion in assistance dogs

As more people need assistance dogs, it’s key to understand how the POMC deletion affects them17. We need to pick and manage these dogs carefully to make sure they do well in their roles17.

Breed Prevalence of POMC Deletion
Labrador Retrievers 23%
Flat-Coat Retrievers Higher than Labradors
Assistance Labrador Retrievers 76%

The table shows how the POMC deletion varies among dog breeds17. It points out the special challenges for assistance dog programs in dealing with this genetic issue17.

Potential Therapeutic Implications for Human Obesity

Research on obese Labrador retrievers could lead to new ways to fight human obesity. The POMC gene, key in energy balance, is found in humans too. Some people share genetic traits with these dogs, affecting their weight18.

This study might reveal how genetics and brain signals link to obesity in humans. By studying the POMC gene and related pathways, scientists could find new treatments. This could help tackle the growing obesity problem worldwide18.

Obesity is a big health worry, affecting 38.8% to 65% of dogs in rich countries19. Finding effective ways to fight obesity in dogs and humans could greatly improve health. It could also reduce the risk of other health problems and make life better for those affected.

The research on Labrador retrievers is exciting for human health. Finding genetic causes and treatments could change how we fight obesity. This study could open new doors to managing and preventing obesity in both dogs and humans18.

Dietary Intervention Impact on Overweight/Obese Dogs
High-protein, extremely low-starch diet Limited loss of lean body mass to about 20%
High-protein, low-carbohydrate diet Promoted higher percentage of weight and fat mass loss compared to high-carbohydrate diet
Diet supplemented with soy isoflavones Helped reduce weight gain in spayed and neutered dogs
Omega-3 polyunsaturated fatty acids (EPA and DHA) Improved mobility in dogs with osteoarthritis

These diets, which work for dogs, might also help humans with obesity19.

“The findings from this study on obese Labradors may provide valuable insights for human health as well.”

As we learn more about the links between dog and human obesity, new treatments could emerge. This research could be a big step towards solving the obesity crisis18.

Conclusion

Research on Labrador retrievers has given us key insights into obesity. A common genetic variant in the POMC gene is linked to weight and food drive20. This mutation is a big factor in obesity risk for Labradors and flat-coat retrievers. It might also affect their trainability20.

This discovery is crucial for both dogs and humans. It could lead to new ways to fight obesity in pets and people21. Labradors often face issues like being overweight, ear problems, and joint issues. This shows we need to take care of their health to make them live longer21.

In short, the study on Labrador retriever obesity has given us a deep understanding. With this knowledge, vets, breeders, and owners can create better ways to prevent and manage obesity. This will help improve the health and life span of Labradors2120.

FAQ

Are Labrador Retrievers prone to obesity?

Yes, Labrador Retrievers are more likely to become obese than other dogs. A recent study found a genetic link to obesity and appetite in Labradors. This might explain why they tend to gain weight easily.

What causes obesity in Labrador Retrievers?

Obesity in Labradors is caused by both genetics and environment. The study discovered a common genetic variant in the POMC gene. This variant is linked to more weight, fat, and a strong desire for food in Labradors.

How can Labrador Retriever obesity be prevented?

While genetics play a role, diet and exercise can prevent obesity in Labradors. Owners should work with their vet to ensure their dog gets the right food and exercise.

How can Labrador Retriever obesity be treated?

Treating obesity in Labradors involves changing their diet and increasing exercise. Sometimes, medication or supplements are needed. Owners should talk to their vet to create a plan for their dog’s weight and health.

Are there any other dog breeds prone to obesity like Labrador Retrievers?

The study also found the POMC gene deletion in flat-coat retrievers, suggesting they might also be at risk for obesity. However, this mutation was not found in 38 other dog breeds. This means Labradors and flat-coat retrievers are especially prone to obesity due to their genetics.

Source Links

  1. New study finds genetic mutation responsible for obesity in a quarter of Labrador dogs – https://www.pdn.cam.ac.uk/news/new-study-finds-genetic-mutation-responsible-obesity-quarter-labrador-dogs
  2. Labrador Retrievers Are More Prone to Obesity Than Other Breeds – https://www.dvm360.com/view/labrador-retrievers-are-more-prone-to-obesity-than-other-breeds
  3. ‘Much more fixated on the sausage’: study sheds light on obesity in labradors – https://www.theguardian.com/lifeandstyle/2024/mar/06/scientists-shed-light-on-gene-mutation-makes-labradors-prone-to-obesity
  4. Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548226/
  5. A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873617/
  6. Genetic variant may help explain why Labradors are prone to obesity – https://www.cam.ac.uk/research/news/genetic-variant-may-help-explain-why-labradors-are-prone-to-obesity
  7. Obesity Research is Going to the Dogs – https://www.the-scientist.com/obesity-research-is-going-to-the-dogs-71863
  8. The Canine POMC Gene, Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354034/
  9. Frontiers | Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study – https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1235821/full
  10. Canine <i>POMC</i> deletion (P187fs) allele frequency in Labrador Retrievers in Brazil – https://www.scielo.br/j/pvb/a/LVvfyxf3gfJwsnX3d3s3wzC/
  11. The Lab Results Are In: Genes Might Be to Blame for Retrievers’ Obesity (Published 2016) – https://www.nytimes.com/2016/07/06/world/what-in-the-world/dog-labrador-retriever-obesity.html
  12. Why fat Labradors can blame their genes – https://www.bbc.co.uk/news/science-environment-68492504
  13. A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs – PubMed – https://pubmed.ncbi.nlm.nih.gov/27157046/
  14. Pro-opiomelanocortin (POMC) Gene Mutation | VCA Animal Hospitals – https://vcahospitals.com/know-your-pet/proopiomelanocortin-pomc-gene-mutation
  15. OMIA:001258-9615: Obesity in Canis lupus familiaris (dog) – OMIA – https://omia.org/OMIA001258/9615/
  16. Retrievers have a mutation that makes them hungrier, study discovers – https://www.dvm360.com/view/retrievers-have-a-mutation-that-makes-them-hungrier-study-discovers
  17. Why Labrador retrievers are more interested in food than other breeds – https://www.eurekalert.org/news-releases/493265
  18. Why Labrador retrievers are more interested in food than other breeds – https://www.sciencedaily.com/releases/2016/05/160503130342.htm
  19. Effects of a therapeutic weight loss diet on weight loss and metabolic health in overweight and obese dogs – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284039/
  20. This Is Why Your Lab Is Fat – https://www.justfoodfordogs.com/blog/lab-overweight.html?srsltid=AfmBOop8O5HvNkDwXXZBmQ2LJDVAGbf4gwvY7FeC0aGybLVNwOYPnk-8
  21. Labrador retrievers under primary veterinary care in the UK: demography, mortality and disorders – Canine Medicine and Genetics – https://cgejournal.biomedcentral.com/articles/10.1186/s40575-018-0064-x

Leave a Comment

Leave a Reply

Your email address will not be published. Required fields are marked *